MSG_PROJECT_QUERY_NEWGUIDS

Generating new GUIDs for the project will cause the installer to behave as a new product.
Are you sure you want to change the GUIDs?

This message requests confirmation for the Project > Generate New GUIDs command. It draws your attention to the fact that with new GUIDs any installers created from the project will behave as if installing a completely different product:

These changes are necessary to create an independent product installer, but should be avoided if you want to maintain backward compatibility with your current installers.

Solution

Click Yes to confirm the changes and generate new GUIDs, or No if you want to retain the current ones.